Epidemiology and Surveillance

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Public Health Weekly Report 2021; 14(33): 2366-2373

Published online August 12, 2021

© The Korea Disease Control and Prevention Agency

Serotypes of imported dengue fever cases in South Korea, 2018-2020

Kim Jae-Seok, Kang Hae Ji, Lim Aram, Lee Ye-Ji, Lee Deog-Yong, and Han Myung-Guk

Division of Viral Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency (KDCA)

Dengue fever is a mosquito-borne disease caused by the dengue virus (DENV), which occurs in several countries. A large number of dengue cases have recently been reported, particularly in Southeast Asia and South and Central America. All DENV infections in Korea are imported cases, and no reports of autochthonous outbreaks in Korea have been confirmed so far. In this article, we analyzed the dengue fever laboratory test data during 2018-2020 to investigate the distribution status of DENV serotypes and the suspected infection area for dengue imported cases in Korea. A total of 2,812 dengue laboratory tests were performed from 2018 to 2020, of which 17.2% were confirmed positive. The number of dengue laboratory tests and patients was highest in August, and most of the suspected infection regions for dengue fever were Southeast Asia and the Philippines. All four serotypes of DENV were introduced into Korea. The serotypes DENV1 and 2 were the most common, followed by DENV3 and DENV4. To block the DENV spread by management of dengue cases will be important to prevent the spread of DENV in Korea by importation from other countries and virus localization. Confirmation of virus importation by continuous analysis of virus serotype and infection origin area could be used as important data for monitoring the occurrence of autochthonous dengue virus in Korea.

Key words Dengue fever, Dengue virus, Serotype

Figure 1. Monthly distribution of imported dengue cases and laboratory tests, 2018-2020

Figure 2. Distribution of imported dengue virus by (A) regions and (B) countries, 2018-2020

Figure 3. Distribution of imported dengue virus serotypes by year, 2018-2020

Figure 4. Distribution of imported dengue virus serotypes by (A) regions and (B) countries, 2018-2020
  1. Jeffrey D Stanaway, Donald S Shepard, Eduardo A Undurraga Yara A Halasa el al. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013. Lancet Infect Dis 2016;16:712-723.
    Pubmed CrossRef
  2. Mohammad Nadir Sahak. Dengue fever as an emerging disease in Afghanistan: Epidemiology of the first reported cases. Int J Infect Dis 2020;99:23-27.
    Pubmed CrossRef
  3. Luca Lazzarini, Luisa Barzon, et al. First autochthonous dengue outbreak in Italy, August 2020. Euro Surveill 2020;25(36):2001606.
    Pubmed KoreaMed CrossRef
  4. Jane P. Messina, Oliver J. Brady, Thomas W. Scott, et al. Global spread of dengue virus types: mapping the 70 year history. Trends Microbiol 2014;22(3):138-146.
    Pubmed KoreaMed CrossRef
  5. Stephen J. Thomas, In-Kyu Yoon. A review of Dengvaxia: development to deployment. Hum Vaccin 2019;15(10):2295-2314.
    Pubmed KoreaMed CrossRef
  6. Sophie Yacoub, Heiman Wertheim, Cameron P. Simmons, Gavin Screaton, Brdget Wills. Cardiovascular manifestations of the emerging dengue pandemic. Nat. Rev 2014;11:335-345.
    Pubmed CrossRef
  7. Jessica Patterson, Maura Sammon, Manish Gard. Dengue, Zika and Chikungunya: Emerging Arboviruses in the New World. WestJEM 2016;17(6):671-679.
    Pubmed KoreaMed CrossRef
  8. Ji-Hyun Park, Dong-Woo Lee. Dengue fever in South Korea, 2006-2010. Emerg Infect Dis 2012;18(9):1525-1527.
    Pubmed KoreaMed CrossRef
  9. WHO. Update on the Dengue situation in the Western Pacific Region, WPR/OMS.
  10. Tsheten Tsheten, Darren J. Gray, Archie C.A. Clements, Kinley Wangdi. Epidemiology and challenges of dengue surveillance in the WHO South-East Asia Region. Trans R Soc Trop Med Hyg 2021;115:583-599.
    Pubmed CrossRef
  11. R Aguas, I Dorigatti, L Coudeville, C Luxemburger, N M Ferguson. Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam. Sci Rep 2019;9:9395.
    Pubmed KoreaMed CrossRef
  12. Satoshi Kutsuna, Yasuyuki Kato, Meng Ling Moi, Akira Kotaki, Masayuki Ota, Koh Shinohara Tetsuro Kobayashi el al. Autochthonous dengue fever, Tokyo, Japan, 2014. Emerg Infect Dis 2015;21(3):517-520.
    Pubmed KoreaMed CrossRef
  13. 질병관리청 보도자료-모기 감시를 통해 뎅기 바이러스 유전자 검출(2019.7.15.).

Epidemiology and Surveillance

Public Health Weekly Report 2021; 14(33): 2366-2373

Published online August 12, 2021

Copyright © The Korea Disease Control and Prevention Agency.

Serotypes of imported dengue fever cases in South Korea, 2018-2020

Kim Jae-Seok, Kang Hae Ji, Lim Aram, Lee Ye-Ji, Lee Deog-Yong, and Han Myung-Guk

Division of Viral Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency (KDCA)

Abstract

Dengue fever is a mosquito-borne disease caused by the dengue virus (DENV), which occurs in several countries. A large number of dengue cases have recently been reported, particularly in Southeast Asia and South and Central America. All DENV infections in Korea are imported cases, and no reports of autochthonous outbreaks in Korea have been confirmed so far. In this article, we analyzed the dengue fever laboratory test data during 2018-2020 to investigate the distribution status of DENV serotypes and the suspected infection area for dengue imported cases in Korea. A total of 2,812 dengue laboratory tests were performed from 2018 to 2020, of which 17.2% were confirmed positive. The number of dengue laboratory tests and patients was highest in August, and most of the suspected infection regions for dengue fever were Southeast Asia and the Philippines. All four serotypes of DENV were introduced into Korea. The serotypes DENV1 and 2 were the most common, followed by DENV3 and DENV4. To block the DENV spread by management of dengue cases will be important to prevent the spread of DENV in Korea by importation from other countries and virus localization. Confirmation of virus importation by continuous analysis of virus serotype and infection origin area could be used as important data for monitoring the occurrence of autochthonous dengue virus in Korea.

Keywords: Dengue fever, Dengue virus, Serotype

Body

Figure 1. Monthly distribution of imported dengue cases and laboratory tests, 2018-2020

Figure 2. Distribution of imported dengue virus by (A) regions and (B) countries, 2018-2020

Figure 3. Distribution of imported dengue virus serotypes by year, 2018-2020

Figure 4. Distribution of imported dengue virus serotypes by (A) regions and (B) countries, 2018-2020

Fig 1.

Figure 1.Monthly distribution of imported dengue cases and laboratory tests, 2018-2020
Public Health Weekly Report 2021; 14: 2366-2373

Fig 2.

Figure 2.Distribution of imported dengue virus by (A) regions and (B) countries, 2018-2020
Public Health Weekly Report 2021; 14: 2366-2373

Fig 3.

Figure 3.Distribution of imported dengue virus serotypes by year, 2018-2020
Public Health Weekly Report 2021; 14: 2366-2373

Fig 4.

Figure 4.Distribution of imported dengue virus serotypes by (A) regions and (B) countries, 2018-2020
Public Health Weekly Report 2021; 14: 2366-2373

References

  1. Jeffrey D Stanaway, Donald S Shepard, Eduardo A Undurraga Yara A Halasa el al. The global burden of dengue: an analysis from the Global Burden of Disease Study 2013. Lancet Infect Dis 2016;16:712-723.
    Pubmed CrossRef
  2. Mohammad Nadir Sahak. Dengue fever as an emerging disease in Afghanistan: Epidemiology of the first reported cases. Int J Infect Dis 2020;99:23-27.
    Pubmed CrossRef
  3. Luca Lazzarini, Luisa Barzon, et al. First autochthonous dengue outbreak in Italy, August 2020. Euro Surveill 2020;25(36):2001606.
    Pubmed KoreaMed CrossRef
  4. Jane P. Messina, Oliver J. Brady, Thomas W. Scott, et al. Global spread of dengue virus types: mapping the 70 year history. Trends Microbiol 2014;22(3):138-146.
    Pubmed KoreaMed CrossRef
  5. Stephen J. Thomas, In-Kyu Yoon. A review of Dengvaxia: development to deployment. Hum Vaccin 2019;15(10):2295-2314.
    Pubmed KoreaMed CrossRef
  6. Sophie Yacoub, Heiman Wertheim, Cameron P. Simmons, Gavin Screaton, Brdget Wills. Cardiovascular manifestations of the emerging dengue pandemic. Nat. Rev 2014;11:335-345.
    Pubmed CrossRef
  7. Jessica Patterson, Maura Sammon, Manish Gard. Dengue, Zika and Chikungunya: Emerging Arboviruses in the New World. WestJEM 2016;17(6):671-679.
    Pubmed KoreaMed CrossRef
  8. Ji-Hyun Park, Dong-Woo Lee. Dengue fever in South Korea, 2006-2010. Emerg Infect Dis 2012;18(9):1525-1527.
    Pubmed KoreaMed CrossRef
  9. WHO. Update on the Dengue situation in the Western Pacific Region, WPR/OMS.
  10. Tsheten Tsheten, Darren J. Gray, Archie C.A. Clements, Kinley Wangdi. Epidemiology and challenges of dengue surveillance in the WHO South-East Asia Region. Trans R Soc Trop Med Hyg 2021;115:583-599.
    Pubmed CrossRef
  11. R Aguas, I Dorigatti, L Coudeville, C Luxemburger, N M Ferguson. Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam. Sci Rep 2019;9:9395.
    Pubmed KoreaMed CrossRef
  12. Satoshi Kutsuna, Yasuyuki Kato, Meng Ling Moi, Akira Kotaki, Masayuki Ota, Koh Shinohara Tetsuro Kobayashi el al. Autochthonous dengue fever, Tokyo, Japan, 2014. Emerg Infect Dis 2015;21(3):517-520.
    Pubmed KoreaMed CrossRef
  13. 질병관리청 보도자료-모기 감시를 통해 뎅기 바이러스 유전자 검출(2019.7.15.).

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